There is therefore without doubt that these bacterias provide a condition necessary for the development of acne. One of the female sexual hormones, estrogen, is usually believed to be involved in the reason behind the disease in girls. Also acne could be caused by genetic aspect which some people believe it is definitely the reason why some set of people cannot avoid the reoccurrence of it. Considering diet and stress as factors, they do not have the ability to cause acne but they could aggravate this disease condition. It has been reported that pimples can lower people’s esteem and cause personal anguish. Even though this serious skin disorder offers plagued so many thousands of people all over the world, there is absolutely no particular product that can be seen as a magic pimples cure.C5aR blockade was discovered to directly raise the ratio of pro-asthma mDCs to anti-asthma pDCs leading to Th2 sensitization, in the absence of allergen, but more so following allergen exposure actually, demonstrating that C5aR prevents cell activation and recruitment. Paradoxically, when C5aR was blocked after allergen exposure, the allergic response was avoided, and the severe nature of asthma-like symptoms was decreased, suggesting that C5aR escalates the body’s response to asthma-inducing stimuli only in an set up allergic environment.