While these are a few of the same disorders that have been associated with AMPK activity in adults, those previous links were made through AMPK’s role as a manager of cellular energy usage. Milbrandt wonders if adjustments in AMPK activity triggered by malnutrition could also be affecting stem cell activity with techniques that boost long-term health threats in developing infants. AMPK’s part reversal in stem cells calls for careful use of the enzyme in cancer therapy, the researchers take note. Recent studies have shown that stem cells may become cancerous, and in those cancers the researchers now believe it might be easier to inhibit AMPK than to activate it.Third quarter sales were significantly impacted by the huge backlog of prescription requests which were submitted previously in the year and were not all filled until the third one fourth. This backlog was eliminated in the third quarter, and fourth quarter sales might be less than third quarter sales.6 million compared to combined gross sales of $14.5 million for the same quarter in ’09 2009. ZANAFLEX product sales are recognized using a deferred revenue recognition model, meaning ZANAFLEX CAPSULES and ZANAFLEX tablets shipments to wholesalers are documented as deferred revenue and only named revenue when end-user prescriptions of ZANAFLEX CAPSULES and ZANAFLEX tablets are reported. As previously projected, the Company expects sales of ZANAFLEX CAPSULES to decline this year 2010.