Deadly Skin Cancer More Common in Organ Transplant Recipients: Study: MONDAY.

Close monitoring for melanoma following a transplant can be important so the disease can be caught at an earlier, even more treatable stage, she added.. Deadly Skin Cancer More Common in Organ Transplant Recipients: Study: – MONDAY, Aug. 17, 2015 – – People who’ve received organ transplants may face an increased risk for the deadly skin cancer melanoma, a fresh study suggests. The researchers said the increased risk might stem from the immune system-suppressing drugs that must be taken to prevent rejection of the brand new organs. The analysis of data from thousands of transplant recipients and melanoma patients in the United States showed that transplant recipients were twice as likely to develop melanoma and three times much more likely to die of the condition than people who had not undergone a transplant.The institutional review board at each study center approved the analysis protocol. After written informed consent was attained from the mother or father or legal guardian, all participants received valganciclovir for 6 weeks.15 Individuals then underwent randomization in a 1:1 ratio to get either continued valganciclovir or placebo for 4.5 months. The dose of the study medication was adjusted regular for growth. Study personnel and the participants’ families were unaware of the randomization assignments.13 Secondary end points prespecified in the protocol included the change in total-ear hearing from baseline to follow-up at 6, 12, and 24 months; change in best-ear hearing from baseline to follow-up at 12 and two years; neurologic impairment at 12 and 24 months; and adverse events resulting in the permanent discontinuation of therapy.