George Du Toit.

George Du Toit, M.B ., B.Ch., Graham Roberts, D.M., Peter H. Sayre, M.D., Ph.D., Henry T. Bahnson, M.P.H., Suzana Radulovic, M.D., Alexandra F. Santos, M.D., Helen A. Brough, M.B., B.S., Deborah Phippard, Ph.D., Monica Basting, M.A., Mary Feeney, M.Sc., R.D., Victor Turcanu, M.D., Ph.D., Michelle L. Sever, M.S.P.H., Ph.D., Margarita Gomez Lorenzo, M.D., Marshall Plaut, M.D., and Gideon Lack, M.B., B.Ch. For the LEAP Research Team: Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy.

Previously released sequencing data13 had been used to screen for recurrent driver mutations in 10 patients; 13 other patients were screened by using targeted sequencing for 111 genes or genetic regions implicated in myeloid cancers14 . We used GraphPad Prism software, edition 5. Multivariate analyses had been performed with the use of R statistical software. Exome and targeted sequencing data were analyzed as explained in Supplementary Appendix 1. Results Stable Clonal Heterogeneity in Chronic-Phase Myeloproliferative Neoplasms To identify individuals who carried mutations in both JAK2 and TET2, we sequenced most exons of the TET2 gene in 246 patients who carried JAK2 V617F.