After the bone marrow cells are harvested, Methodist and Bruckner cardiovascular surgeon Dr. Michael Reardon perform the bypass procedure. The cells are processed to split up stem cells from bone marrow simultaneously. After executing the bypass, the surgeons after that inject the stem cells into the subject’s heart, and the procedure is comprehensive. The Methodist DeBakey Heart & Vascular Center is one of only three centers in the united states to have this study available.In contrast, some DNA mutations that arise in the protein-coding sequence can completely inactivate a gene. We tested the hypothesis that protein-inactivating mutations in NPC1L1 reduce both LDL cholesterol rate and the chance of cardiovascular system disease. We sequenced the coding regions of NPC1L1 in a large number of persons, identified carriers of mutations that inactivate this gene, and established whether persons who bring a heterozygous inactivating mutation had a lower LDL cholesterol rate and a lower threat of cardiovascular system disease than noncarriers of these mutations. All scholarly study individuals provided written informed consent for genetic studies. The first and last authors designed the scholarly study.